When using digitalis drugs, care should be taken to avoid electrolyte disturbances, which can easily lead to digitalis toxicity. In addition, it is important to avoid excessive dosage of digitalis drugs in the process of application, which may cause digitalis toxicity. Patients with atrial fibrillation are often treated with beta-blockers, calcium channel blockers, and digitalis to control the ventricular rate. In addition, attention should be paid to electrolyte disorders, especially hypokalemia, which can easily lead to poisoning and malignant arrhythmias when digitalis drugs are used, and attention should be paid to correcting electrolyte disorders. The application of digitalis cardiotonic drugs should be restricted within 72 hours of the acute phase of coronary artery disease, acute coronary syndrome, and acute myocardial infarction.