The quadruple therapy consisting of bismuth + proton pump inhibitor (PPI) + two antimicrobial drugs is routinely recommended as the first-line treatment option for Helicobacter pylori (HP) infection. 1. Antibiotics: H. pylori is a spiral, gram-negative, microaerobic bacterium. Commonly used antibiotics include clarithromycin, levofloxacin, amoxicillin, furazolidone, and metronidazole, two of which are capable of eradicating HP. 2. PPI: commonly used drugs include omeprazole, esomeprazole, rabeprazole, etc., which can reduce the secretion of gastric acid and protect the gastric mucosa, and play a synergistic role. 3. Bismuth: commonly used drugs are bismuth potassium citrate capsules, bismuth pectin, etc. Bismuth forms a stable colloid on the surface of gastric mucosa, which is very favorable for direct contact and killing H. pylori. The addition of bismuth can increase the eradication rate of HP. Empirical treatment regimens generally recommend a 10-14 day course of therapy, with an eradication rate of more than 90%. The medication is usually discontinued for more than one month after 14 days of treatment and then the H. pylori test is repeated. There are adverse reactions and variations in the above medications, and the dosage and usage of each regimen should be in accordance with the doctor’s instructions. At the same time, abstain from smoking and alcohol, avoid spicy and stimulating food intake, eat a regular diet, and take the medication on time to avoid interruptions, so as to avoid affecting the effect of the eradication of HP. The following is a summary of the results of the program.