Inexplicable swelling and pain in the toes, need to consider soft tissue injury, tenosynovitis, gout, as well as vascular disease, diabetes and so on. 1. Soft tissue injury: inexplicable swelling and pain in the toes, may be due to walking too much or shoes crowded feet, resulting in soft tissue damage to the toes, you can carry out the local ice packs to relieve pain. 2. Tenosynovitis: due to walking more frequently, after a long period of exercise, the tendon sheath of the foot will appear inflammation, resulting in edema of the tendon sheath, localized bruising, resulting in swelling and pain symptoms. 3. Gout: synovitis, which may be caused by gout, and elevated blood uric acid can lead to localized swelling and pain in the toes. 4. Vascular disease: the presence of varicose veins, microcirculation disorders and other diseases, will lead to blood circulation in the foot, may lead to toe swelling and pain. 5. Diabetes mellitus: diabetes mellitus is a typical complication of patients with diabetic foot, due to peripheral circulatory disorders can lead to the gradual emergence of numbness, swelling and pain in the toes or even gangrene. Inexplicable swelling and pain in the toes may also be caused by other reasons, it is recommended to consult a doctor in a timely manner, a clear diagnosis, for treatment.