The term “high epinephrine” generally refers to high plasma free epinephrine, which may be caused by pheochromocytoma. Pheochromocytoma originates from adrenal medulla, sympathetic ganglia and chromophilic tissues in other parts of the body, and the tumor releases excessive epinephrine, norepinephrine and dopamine intermittently or continuously. Clinical manifestations are variable, with typical episodes characterized by paroxysmal increases in blood pressure with tachycardia, headache, sweating, and pallor. Blood or urine catecholamines or their metabolite 3-methoxy-4-hydroxymuscarinic acid (VMA) may be measured during an attack, and a significant increase is suggestive of pheochromocytoma. When high plasma free adrenaline is detected it is recommended to seek medical attention under the supervision of a doctor.