Burning sensation without skin surface abnormality may be caused by multiple peripheral neuritis, herpes zoster, thromboembolic vasculitis and other diseases, which can be improved by general treatment, medication, surgery and other ways. 1. Multiple peripheral neuritis: If there is no abnormality on the surface of the skin caused by multiple peripheral neuritis but there is a burning sensation, the patient can do appropriate daily exercise and ensure sufficient sleep. You can follow the doctor’s instructions for intravenous glucocorticoid drugs, such as dexamethasone, hydrocortisone, etc., to play the role of immunosuppression and anti-inflammatory. 2. Herpes zoster: Herpes zoster may also cause the skin surface is not abnormal but there is a burning sensation, patients try to wear loose clothing, can reduce friction. Antiviral drugs such as acyclovir and famciclovir can be taken as prescribed by the doctor. Pain can be oral acetaminophen, ibuprofen and other non-steroidal anti-inflammatory drugs, to play the effect of analgesia. 3. Thromboembolic vasculitis: the skin surface is not abnormal but there is a burning sensation may also be caused by thromboembolic vasculitis, the patient can follow the doctor’s instructions to take low molecular heparin and other drugs to prevent the formation of blood clots. Patients can also undergo lumbar sympathetic neurotomy, which can effectively treat resting pain in the limb. There are more reasons for the burning sensation without any abnormalities on the surface of the skin, so it is recommended to go to a regular hospital and cooperate with the doctor to standardize the treatment. Drugs need to be used in accordance with medical advice.