There is no specific standard for how long it takes for premature ovarian failure to lead to amenorrhea, because the degree of ovarian function decline varies. If a woman’s ovarian function declines, usually from diminished ovarian reserve function to ovarian failure, the patient will go through a transition period ranging from a few years, and the patient will show frequent or scanty menstruation, with a significant decrease in menstrual flow, and then amenorrhea may occur. If a woman is menopausal before the age of 40, she may experience a range of symptoms of low estrogen levels, such as hot flashes and sweats, a dry burning sensation in the reproductive tract, loss of libido, osteoporosis, changes in mood and cognitive function, and cardiovascular symptoms. If the diagnosis of premature ovarian failure is confirmed, it is recommended to consult a doctor in time, improve the relevant examination, and can take hormone supplementation therapy as prescribed by the doctor, which is mainly able to alleviate the symptoms of low estrogen, and can also have a certain preventive effect on cardiovascular diseases and osteoporosis.