Premature ovarian failure is a phenomenon in which a woman develops diminished ovarian function before the age of 40, and its symptoms mainly include menstrual changes, low fertility or infertility, hot flashes and sweats, loss of libido, and osteoporosis. Its treatment mainly includes general treatment, hormone supplementation, fertility-related management and other treatments. 1. General treatment: attention should be paid to healthy diet, regular exercise, avoiding exposure to reproductive toxic substances and appropriate supplementation of vitamin D and calcium. 2. Hormone supplementation therapy: mainly applying estrogen-progestin sequential therapy, commonly used are estradiol valerate tablets, dydrogesterone tablets and so on. The specific dosage and timing of the medication should be based on one’s own condition and under the guidance of the doctor. 3. Fertility management: It is recommended that patients with premature ovarian failure should give birth as early as possible, and assisted reproductive technologies such as in vitro fertilization-embryo transfer can be applied if necessary. 4. Other treatments: patients with ovarian insufficiency will have increased risk of osteoporosis and other diseases, so they should pay attention to maintain a healthy life, keep away from risk factors and pay attention to self-protection. If there is any discomfort, it is recommended to consult a doctor in time for diagnosis and treatment.