1, people with obvious cardiovascular diseases: such as hypertension (significant increase in blood pressure or target organ heart, brain and kidney damage), coronary heart disease, rheumatic heart disease, cardiomyopathy, severe arrhythmia, history of cerebral thrombosis or cerebral hemorrhage, cerebrovascular malformation; 2, chronic obstructive pulmonary disease of more than moderate degree, frequent episodes of bronchial asthma, bronchiectasis, active tuberculosis, occupational pneumoconiosis; 3. Various types of marked anemia, thrombocytopenic purpura or bleeding disorders with coagulation dysfunction; 4. Active gastric or duodenal ulcer disease, acute infectious hepatitis, active chronic hepatitis, other chronic liver disease, spleen disease; 5. Acute or chronic kidney disease with active inflammation or with renal dysfunction; 6. Epilepsy, hysteria, schizophrenia; 7. Uncontrolled diabetes mellitus, severe obesity. Adrenal, thyroid, gonadal diseases and their dysfunctions; 8, ever diagnosed with plateau pulmonary edema, plateau cerebral edema, plateau hypertension with significant increase in blood pressure, plateau heart disease, plateau erythrocytosis.