The fact that one eye is nearsighted by 350 degrees and the other eye is normal is a sign of refractive error and needs to be corrected. Many people have two eyes with different degrees, the refractive difference between the two eyes is called physiological refractive error if the difference is less than 100 degrees, but if it is more than 100 degrees, various visual problems may occur, so it needs to be corrected in time. Due to the difference in refractive error between the two eyes, there may be a misalignment of objects when looking at things, which may even cause strabismus or amblyopia, which can be corrected by wearing frames or corneal contact lenses, and refractive surgery can be considered to correct the visual acuity according to the actual situation of the patient when he/she becomes an adult. It is recommended that patients go to the hospital in time, complete the relevant examinations, and under the guidance of the doctor for treatment.