What does it mean to be a high-risk group?

For example, for AIDS, patients with a history of sexual promiscuity, homosexuality, intravenous drug addiction or repeated use of blood products are at high risk for the disease; 2, for tuberculosis, patients with close contact with tuberculosis patients, patients with diabetes or long-term use of immunosuppressive drugs, and AIDS patients are at high risk for tuberculosis disease; 3, patients with long-term smoking and family history of tumor disease are at high risk for tumor disease; long-term exposure to radioactive toxins are at high risk for blood diseases.