What should I do next if I suspect oral cancer? Once oral cancer is suspected, one should go to the oral and maxillofacial surgery department of a dental hospital, or a tumor hospital, or the stomatology department, head and neck surgery department of a large general hospital. The initial clinical judgment of the specialist is more authoritative. If cancer is still suspected, the patient will be arranged to undergo a small surgery called biopsy, in which a small piece of diseased tissue will be taken from the oral cavity, and after fixation, staining and other complicated procedures, a pathological section will be made, and analyzed and judged by a microscope to see whether it is cancer or not. Do I have to have a biopsy? Will biopsy cause cancer cells to metastasize? Pathologic tissue biopsy must be done. This is because some mouth ulcers that look like oral cancer to the naked eye are actually not oral cancer. Moreover, there are various types of oral cancer; the treatment varies from one oral cancer to another, and some types do not even require surgical treatment. Only through pathological tissue biopsy can the diagnosis and its corresponding treatment be determined. In addition, according to current evidence-based medicine evidence, biopsy does not increase the chance of cancer metastasis. Can a biopsy be taken on an outpatient basis? Does it hurt? If an abnormal lesion tissue is found in the mouth, biopsy can be done on an outpatient basis when the lesion is on the surface of the oral mucosa and relatively anterior. However, if the abnormal lesion tissue in the mouth is in the deeper part of the oral mucosa, sometimes it is necessary to arrange hospitalization for biopsy surgery. With modern medical advances, biopsies can be performed with little or no pain. How accurate is the histopathologic examination? How many times will it be done? Once a tissue biopsy is reported to be cancerous, it can be assumed to be cancerous. If it is not cancer, it should be analyzed specifically. It is possible that the selected lesion is atypical, or the cut tissue is not large enough, etc. The clinician’s advice should be followed, and another biopsy should be performed if necessary.