Pancreatic discomfort or bloating is not necessarily a pancreatic lesion, but also gastrointestinal diseases, such as chronic gastritis and gastric ulcer. Chronic gastritis and gastric ulcer, due to the impaired barrier function of the gastric mucosa, gastric acid stimulation will damage the gastric mucosa and affect the digestive function of the stomach, resulting in epigastric distension and epigastric pain, which is mistaken for pancreatic lesions. Gastroscopy is recommended to rule out gastrointestinal diseases. If pancreatic disease is suspected, an enhanced CT examination of the pancreas can be performed and combined with blood amylase and other related tests to determine the cause. When pancreatic discomfort occurs, it is recommended to consult a doctor in time, follow the doctor’s instructions for further examination, clarify the cause with the help of the doctor, and carry out targeted treatment or therapy.