In general, it is very difficult to do surgery for advanced bile duct cancer, so the miracle of complete recovery has not been found in clinical practice yet. We should not put our hope on miracles, but need effective anti-tumor, nutritional support and pain relief treatment. We can hope for a miracle, but we should focus on minimizing the pain and prolonging the survival. In advanced stage, only local radiotherapy can be considered, and systemic chemotherapy can be done according to the patient’s condition. In addition, it can be combined with immunotherapy and Chinese medicine treatment, which can also prolong the survival period. Jaundice may occur in the late stage of bile duct cancer, which can be combined with interventional therapy to reduce the symptoms of jaundice.