Parkinson’s patients take medication after the reverse serious, consider the Parkinson’s disease end of the dose phenomenon, on – off phenomenon, may also be caused by the deterioration of the disease. 1. End-of-dose phenomenon: Parkinson’s disease patients will experience end-of-dose phenomenon after a period of medication, and the duration of the medication effect will become shorter after taking the medication. There may be a phenomenon that the disease becomes worse after taking the medication. 2. On-off phenomenon: Parkinson’s disease patients in the long-term application of levodopa drugs, there may be some adverse drug reactions, such as a few seconds or minutes of sudden stiffness, inactivity, this phenomenon for the “off”, and then the symptoms suddenly improve, for the “on”. This phenomenon is called “off”, and the sudden improvement of symptoms is called “on”. 3. Deterioration: Parkinson’s disease is a kind of incurable disease, can only control the condition through active treatment, but to the late stage of the disease or when combined with some other underlying diseases, it may aggravate the deterioration of the disease, and the symptoms of taking medication may be reversed to serious. Parkinson’s disease patients who take medication after the reversal of the seriousness of the disease, should promptly seek medical attention, strictly comply with the medical prescription treatment, do not delay the condition.