Syphilis is not a stage 1 disease, but a stage 1, stage 2, and stage 3 syphilis. Stage I syphilis tends to occur within three weeks after infection, stage II syphilis tends to occur six to twelve weeks after infection, and stage III syphilis tends to occur two years after infection. 1. Stage 1 syphilis: In the early stages of syphilis, there are obvious hard nodules at the site of infection. As the disease progresses, vesicles and ulcers can form, and the chancre tends to develop on the genitals, causing edema of the foreskin. In women, the chancre may occur at the vaginal opening, labia, cervix, etc. The lymph nodes may be slightly enlarged at the onset of the disease. 2. Stage 2 syphilis: Stage 2 syphilis usually occurs six to twelve weeks after infection. The lesions may develop extensively and the chancre gradually disappears, after which other symptoms such as syphilitic rashes, headaches, loss of appetite, joint pains, and enlarged tonsils may appear, suggesting that attention should be paid to them. 3. Stage III syphilis; Stage III syphilis is usually more dangerous and is likely to occur in patients who have been infected for more than 2 years. If the disease is not controlled in time or medication is not correct, it can cause nodular syphilis rash, syphilitic gumma, bone syphilis, ocular syphilis, neurosyphilis, cardiovascular syphilis, and involve blood vessels, internal organs and head. Syphilis spreads throughout the body and can cause symptoms such as pain in the mouth and tongue, general malaise, fever, and enlarged lymph nodes throughout the body. The manifestations of syphilis are complex and varied, if the patient has painless erythema, papules, enlarged lymph nodes and other manifestations in the genital area, it is recommended to go to the dermatologic and venereal diseases department of the hospital as soon as possible.