Normally, total bilirubin 21.6 μmol/L is considered mildly elevated, and direct and indirect bilirubin 21.6 μmol/L are considered elevated. There are three types of bilirubin, and their normal ranges are total bilirubin: 1.71-17.1 μmol/L, direct bilirubin: 0-3.42 μmol/L, and indirect bilirubin: 1.7-10.2 μmol/L. Either bilirubin test result of 21.6 μmol/L indicates that bilirubin is elevated. Elevated bilirubin can be categorized into physiological and pathological elevations. 1. Physiological increase: It is related to frequent late nights, strenuous exercise, long-term alcohol consumption and overwork. It can be normalized by quitting drinking and getting enough sleep. 2. Pathological increase: mainly related to chronic active hepatitis, acute jaundice hepatitis, hepatic fibrosis, cirrhosis, choledocholithiasis, liver failure and other diseases, we should consult the doctor in time, combined with the patient’s symptoms, medical history, imaging tests, transaminases and other indicators for comprehensive analysis. If the patient’s bilirubin test result is abnormal, it is recommended to consult the doctor in time, after clarifying the cause of the disease, and then carry out targeted treatment or therapy under the guidance of the doctor.