An electrocardiogram suggesting a low, flat, inverted t-wave requires formal consultation with a cardiologist. If myocardial ischemia is present, further coronary vascularization is required. If it is myocarditis, hospitalization is needed for active treatment. If hypertensive hypertrophic strain, must regulate blood pressure control. Myocardial ischemia, ECG will occur t-wave low flat inversion, severe myocardial infarction will appear huge inverted t-wave. Combined with the patient’s chest tightness and chest pain typical myocardial ischemia symptoms, laboratory tests cardiac enzymes, troponin is elevated to determine. Severe myocardial ischemia has the risk of death, must actively consult the cardiology department, regular treatment, if necessary, coronary angiography intervention. In myocarditis, the myocardium is damaged, and the ECG will have low t-wave and inversion. Combined with the history of cold and fever, accompanied by chest tightness, fatigue, palpitations (rapid heartbeat, often accompanied by panic) and other symptoms, elevated cardiac enzymes, cardiac ultrasound suggests that the heart is enlarged to confirm the diagnosis. Patients need to strengthen nutrition, pay attention to rest, actively hospitalized antiviral treatment, nutritional myocardium. If the hypertension is not well controlled for a long time, left ventricular hypertrophy will occur, and the electrocardiogram will have low and flat inverted t-wave. Combined with the patient’s symptoms and history of hypertension, this diagnosis can be considered. The patient should actively consult the cardiology department to adjust the medication, control the blood pressure, and reduce the damage to target organs such as the heart, brain, and kidney. If there is no specific etiologic finding after examination, no special treatment can be given for the time being, and regular follow-up ECG examination is needed. Therefore, if T-wave flattening and inversion occurs, it is necessary to consult a doctor to clarify the cause of the disease and then give active symptomatic treatment or follow-up.