A child’s fever may last 1 to 2 days or 2 to 3 days after rabies vaccination. Rabies vaccine is an inactivated vaccine used to prevent rabies, a viral zoonotic disease. For humans, once an individual develops an illness due to infection with the rabies virus, the case fatality rate is almost 100%. The lack of an effective treatment for rabies makes prevention all the more important. Young children who have been scratched or bitten by an animal suspected of having the disease must be vaccinated against rabies. However, after the rabies vaccination, it is very likely to have the adverse reaction of fever, which is usually temporary and will disappear after 1~2 days or 2~3 days, and can be handled by physical cooling. However, if persistent high fever occurs, prompt medical attention should be sought. The overall safety and efficacy of rabies vaccine is recognized. Parents should pay attention to the observation of their children after rabies vaccination. Ordinary and mild adverse reactions generally do not require special treatment, but if there are abnormal and serious adverse reactions, seek professional medical help in time.