Hypofractionated carcinoma is a pathological diagnosis that mainly indicates the higher malignancy of the patient’s cancer and is a qualitative description of the tumor rather than a staging statement. Generally, according to the morphology of tumor cells under the microscope of pathology department, they are classified as highly differentiated, moderately differentiated, hypofractionated and undifferentiated cancer. Highly differentiated tumors, with low malignancy, have a better prognosis; poorly differentiated tumors, with high malignancy, have a worse prognosis; and undifferentiated tumors, with extremely high malignancy, have the worst prognosis. The more differentiated tumor cells are close to normal cells, the more mature they are, which is usually called high differentiation, also known as grade I. If tumor cells are too poorly differentiated and extremely immature, but still retain some traces of the source tissue, they are called low differentiation, or grade III. Those in between are called intermediate differentiation, or grade II. However, sometimes the tumor cells are so poorly differentiated that no signs of the tissue of origin can be found at all, then it is called undifferentiated. And the stage is based on the quantitative analysis of the tumor made by CT, MRI and other related imaging tests. If the tumor is small and there is no local as well as distant metastasis, it is early stage, while imaging tests reveal the presence of distant metastasis, it is advanced stage.