The time of metastasis of hypofractionated cancer should be analyzed on a case-by-case basis, and cannot be judged by the degree of differentiation alone. Cancer cells are classified into highly differentiated, moderately differentiated, poorly differentiated and undifferentiated according to the degree of differentiation. The degree of differentiation is inversely proportional to the degree of malignancy, the higher the degree of differentiation, the lower the degree of malignancy. Therefore, hypofractionated carcinoma is only more malignant, but it does not mean that metastasis will occur. It is also necessary to clarify what part of the tumor is involved, and the possibility of metastasis varies among different parts of the tumor, and it is necessary to observe whether the tumor has metastasis from lymph nodes or other organs. Generally speaking, hypofractionated cancer is more malignant, so metastasis occurs earlier. Patients with hypofractionated cancer should be detected and treated early, maintain a good mental state, face and cooperate with doctors’ treatment with a positive attitude, take medication on time and do review regularly.