More than 40 years of long-term hormone use may cause gastrointestinal diseases, endocrine disorders, osteoporosis, pigmentation, etc. 1. Long-term use of hormones may lead to gastrointestinal diseases, such as gastric ulcer, gastroenteritis, etc., patients will be accompanied by nausea, vomiting, diarrhea and other manifestations. 2. Hormones can lead to endocrine disruption, resulting in obesity, acne and other phenomena, and may also lead to infertility in serious cases. 3. Hormones may also lead to a lack of calcium, which can lead to osteoporosis, and in severe cases may also lead to fractures. 4. Hormones can damage the skin barrier structure and function to make the skin thinner, but also can cause melanin produced by melanocytes to increase melanin, ultimately leading to hyperpigmentation, dull skin. Eating hormones for a long time is harmful to the body, in the process of eating hormones must pay attention to their own changes, there is a serious reaction to the need to adjust the dosage of drugs under the guidance of a doctor.