The enzyme acetaldehyde dehydrogenase is mainly used for alcohol metabolism and cannot be supplemented outside the body. Its level and activity are mainly related to the individual’s constitution and genes. When drinking too much alcohol, the body can be assisted to metabolize alcohol through the use of drugs such as glucose and naloxone. Acetaldehyde dehydrogenase is a type of aldehyde dehydrogenase, responsible for catalyzing the oxidation of acetaldehyde to acetic acid, which is mainly responsible for the metabolism of alcohol. The enzyme ethanol dehydrogenase in the liver can oxidize ethanol to acetaldehyde, and the resulting acetaldehyde serves as a substrate to be further converted to acetic acid catalyzed by acetaldehyde dehydrogenase. If the patient’s body lacks the enzyme acetaldehyde dehydrogenase, it may lead to a large accumulation of acetaldehyde in the body and symptoms of toxicity. Patients will experience symptoms such as flushing of the skin on the face and neck, dizziness, vomiting, etc. In severe cases, they may also experience a drop in blood pressure, impaired consciousness, or even spasms. If the patient drinks too much alcohol, glucose can be used in moderation to replenish energy, accelerate the decomposition and metabolism of alcohol, and promote urination; it can also be used in conjunction with the use of antidepressant drugs such as naloxone to accelerate the metabolism and decomposition of alcohol. Acetaldehyde dehydrogenase cannot be supplemented in vitro, so it is recommended that patients try to drink as little alcohol as possible.