Soreness in the middle of the waist in the morning can be caused by the following reasons: First, rheumatoid, when rheumatoid involvement of the spine, can have the symptoms of soreness in the middle of the waist in the spine in the morning, can be accompanied by pain in the joints all over the body, can be accompanied by morning stiffness, then we need to check the spinal X-ray film, CT, and blood tests, to carry out the anti-rheumatism, anti-rheumatism treatment at an early stage. Second, ankylosing spondylitis, ankylosing spondylitis patients can also have the symptoms of soreness in the middle of the waist in the morning, can be accompanied by morning stiffness, can have pain in the sacroiliac joints, soreness and discomfort, can involve the entire spine, then we should check the spinal X-ray film and CT, MRI and blood tests, early treatment of rheumatoid drugs, and regular review.