Pain in the brain during a cold is actually a headache, which is clinically caused mainly by a decrease in the immunity of the organism being infected by common viruses, bacteria, mycoplasma, chlamydia and other pathogens, causing inflammatory changes in the mucous membrane of the upper respiratory tract, including the nasal cavity, pharynx, and throat mucosa, which are markedly congested, edematous, and exuding inflammatory secretions. These inflammatory secretions contain a large number of live and dead pathogens and inflammatory factors, which then cause inflammatory irritation of the upper respiratory tract mucosa, and touching the corresponding peripheral nerves, such as the trigeminal nerve, causes headache. Clinically, symptomatic drugs can be chosen to relieve the symptoms, such as Yuanhu Pain Relief Drops and Ibuprofen.