Epilepsy is a common neurological disorder that can be effectively controlled by medications in the vast majority of cases. However, in clinical practice, cases of epilepsy treatment failure are still rare. The common reasons for this are: 1. Diagnostic errors. Such as syncope, hypoglycemia, tic disorder, sleep disorder, abnormal movements, hysteria and other non-epileptic diseases misdiagnosed as epilepsy. 2. Improper drug selection. Incorrect diagnosis of seizure classification and syndrome leads to incorrect drug selection, which not only fails to control seizures but also aggravates them. For example, carbamazepine, oxcarbazepine, and Toltea can aggravate myoclonic seizures. Carbamazepine. Phenobarbital can aggravate aphasic seizures in children. 3. Late treatment. Early and appropriate antiepileptic treatment is the key to successful epilepsy treatment. 4. Incorrect dose of medication and failure to test drug concentration. 5. Poor compliance. A good doctor-patient relationship is the key to increasing the compliance of the child. 6. Non-individualized treatment. 7, unreasonable combination of drugs. 8.Neglect the adverse drug reactions. 9.Not paying attention to the treatment of etiology and precipitating factors. 10.Discontinuation of medication too early or withdrawal too fast.