Thirty-five did not have menstruation, the breasts are very swollen and painful, checked the urine is not pregnant refers to the delay of menstruation, may be physiological phenomenon, may also be due to disease. Thirty-five is a normal childbearing age, the absence of menstruation, usually consider the case of pregnancy, but the urine test showed no pregnancy, if at the same time ultrasound suggests that no gestational sacs, may be due to delayed menstruation. Delayed menstruation refers to a delay in menstruation for more than 7 days or 10 days without menstruation, may be due to stress, endocrine disorders and other reasons, if only a delay in menstruation, and then return to normal, generally do not need special treatment, to maintain a stable mood and optimistic state of mind, in addition to the breast swelling and pain may be the premenstrual syndrome, and patiently wait for menstruation can be. It may also be due to pathological reasons, such as uterine adhesions, polycystic ovary syndrome, pituitary tumors, etc. It may also be due to the use of hormonal drugs, such as emergency contraceptive pills, etc., and should be treated according to the relevant causes. If menstruation does not come for a long period of time, you should go to the hospital for checkups and reasonable treatment under the doctor’s guidance after a clear diagnosis.