Hives taking loratadine ineffective can take other types of antihistamines, or may be a single treatment is not effective, can be combined with two antihistamines to take. If the patient has urticaria, when taking loratadine is ineffective you can take other antihistamines orally as prescribed by the doctor, such as cetirizine, ebastine, imipramine, etc., all of which are able to reduce the allergic reaction of urticaria. When the symptoms are not relieved, you can take two antihistamines at the same time under the guidance of the doctor, such as cetirizine combined with ebastine, etc., can enhance the efficacy. If the above treatment is still ineffective, it can be combined with immunosuppressants such as cyclosporine. If necessary, biological agents such as omalizumab can be used. Urticaria patients taking loratadine is ineffective, it is recommended to go to the hospital, under the guidance of the doctor to standardize the treatment, the specific use of drugs need to comply with medical advice.