Patients with fever in the heart of the hands and feet at night and difficulty in falling asleep may have insomnia belonging to the cardiorenal and renal dysfunction (cardiac fire and renal yin deficiency, dysfunction of the physiological functions of the heart and kidneys) syndrome, and may choose to take Liufei Di Huang Pill combined with Jiaotai Pill for treatment. However, the specific cause and medication should be decided by the doctor according to the patient’s other symptoms. If the patient shows difficulty in falling asleep, hot flashes (a burst of heat), night sweating (abnormal sweating after falling asleep, sweating stops after waking up), five heart-heat (heat in the heart of the hands and feet, and self-consciousness of the heart and chest being irritated), lumbar and knee soreness (feeling of soreness and weakness in the lumbar region and knees), and disturbed and sleeplessness (disturbed and hot feeling in the heart, symptom of insomnia), the insomnia may be attributed to the syndrome of non-interaction between the heart and kidneys. Liu Wei Di Huang Wan (六味地黄丸) is used for dizziness and tinnitus caused by kidney yin deficiency, soreness and weakness of the waist and knees, bone vapor and tidal fever (a burst of heat, feeling that the heat is penetrating from the inside of the bones to the outside), and night sweating and spermatorrhea. Jiaotai Pill is used in cases where the heart is overheated and the heart and kidneys are not in harmony with each other. Symptoms include restlessness with palpitation (violent heartbeat and panic), or sleeplessness at night, and sores on the mouth and tongue. Prompt medical attention is recommended in case of discomfort. If medication is needed, it should be diagnosed by a doctor and regulated according to the doctor’s prescription.