Syphilis in pregnancy should be treated as soon as possible with reasonable medication and, if necessary, termination of pregnancy should be considered. Syphilis in pregnancy is clinically known as syphilis of pregnancy, because the disease may be transmitted to the fetus through the pregnant woman, seriously harming the health and safety of the pregnant woman herself and the fetus in her body, therefore, once diagnosed with syphilis of pregnancy, it is necessary to receive treatment as soon as possible. In early pregnancy, syphilis of pregnancy can be treated by intramuscular injection of procaine penicillin, with 15 consecutive days as a course of treatment, one course of injection in the first trimester of pregnancy, and one course of injection in the last trimester of pregnancy; erythromycin can be used for those who are allergic to penicillin, but the use of tetracycline and doxycycline is prohibited, and penicillin is required to be applied to supplement the treatment of the fetus after birth. During pregnancy, women should always go to the maternity checkup on time and seek professional help when they find any abnormality in their body.