Fusidic acid cream and retinoic acid cream are two different drugs, different indications, can not directly compare which is better, and different patients use the same drug to treat the same disease, the efficacy also varies from person to person, only suitable for the condition is the best. 1. Fusidic acid cream: belonging to the antibiotic class of drugs, commonly used in the treatment of staphylococcus, streptococcus, propionibacterium acnes and other bacteria caused by skin infections, such as impetigo, boils, folliculitis, acne vulgaris, furuncles, acne vulgaris. 2. Vitamin A acid cream: it belongs to keratolytic drugs and is often used in the treatment of various kinds of acne, keratosis pilaris and seborrheic dermatitis, such as acne vulgaris, flat warts and follicular keratosis pilaris. It is recommended that patients choose the appropriate medication for their condition under the guidance of a doctor, and avoid using medication privately to avoid delaying their condition.