Appendicitis that occurs for three days without pain but with fever may be the result of the formation of a periappendiceal abscess, at which point non-surgical treatment is usually the treatment of choice. Acute appendicitis if not treated in time within three days, appendicitis may appear gangrenous or perforated, over time, the perforated appendix will be wrapped by the omentum and intestinal tube, forming an inflammatory mass or periappendiceal abscess. On examination, the right lower abdomen can be found to be full and a mass can be palpated that is relatively fixed and not well defined. Patients with periappendiceal abscesses may experience reduced abdominal pain or pain that is not obvious due to decreased pressure in the abdominal cavity; increased inflammation and inflammatory factors in the blood leading to increased temperature and white blood cell count. Non-surgical treatment should be chosen for patients who have had the disease for more than 72 hours or who have formed an inflammatory mass. Effective intravenous antibiotics such as ceftriaxone sodium, levofloxacin combined with metronidazole can be used for anti-infection treatment, and intravenous rehydration therapy. If you feel unwell, please consult a doctor. The use of medication should be in accordance with the doctor’s prescription.