Most of the causes of pediatric acromegaly are not clear, but the development of a few patients may be related to genetic factors, environmental factors, immunodeficiency and so on. 1. Genetic factors: most of the children with SODY and other gene mutations, some patients have a family history of autosomal dominant inheritance. 2. Environmental factors: some scholars believe that the onset of acromegaly is related to metal poisoning, which may be caused by frequent contact with toxic substances, such as heavy metals, during pregnancy or in children. 3. Immunodeficiency: the increase of autoantibodies in the child’s body, considering that it may be related to autoimmunity. Pediatric acromegaly may also be related to other factors, such as viral infections, once diagnosed, we must actively cooperate with the doctor to take treatment.