High creatinine, normal urine routine, urea nitrogen and uric acid may be caused by physiological factors such as higher muscle content or eating more meat; or it may be caused by pathologic factors such as hypertensive renal damage, post renal acute kidney injury and other diseases. 1. Physiological factors: some patients with elevated creatinine may be caused by their high muscle content, or eating more meat and exercising more, without obvious renal diseases, so urine routine, urea nitrogen, uric acid and other related tests are all normal. 2. Pathological factors: such as hypertensive renal damage, or obstruction and other post renal factors caused by acute kidney injury, can lead to creatinine increase, but urine routine, urea nitrogen, uric acid may be normal. High creatinine, urine routine urea nitrogen and uric acid are normal may also have other reasons, it is recommended to go to the regular hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.