After using Simeglutide, you can take Metformin under the supervision of your doctor. Simeglutide is a glucagon-like peptide receptor agonist indicated for type 2 diabetes mellitus, and common adverse reactions are gastrointestinal reactions such as nausea, diarrhea, and vomiting. It is contraindicated in those who are allergic to the active ingredient or excipients of the product. Metformin is a biguanide glucose-lowering drug, and adverse reactions such as nausea, vomiting, hypoglycemia, headache, and fatigue may occur after taking this drug. The drug should not be used by people who are allergic to the drug, severe renal failure, serious infections, trauma, hepatic insufficiency, and acute alcoholism. After using Simeglutide, if the blood sugar control is not good, you can take Metformin under the guidance of a doctor, during the use of the drug to monitor the changes in blood sugar, panic, sweating, trembling and other symptoms of hypoglycemia, be sure to adjust the dose of the drug in a timely manner. The application of simethicone and metformin should be under the guidance of a doctor, and should not be used arbitrarily on its own.