Difficulty in breathing at night and being fine during the day may be caused by physiological factors such as poor indoor air circulation and stuffiness at night. It may also be caused by bronchial asthma, left heart failure and other diseases. Patients can be treated with medication and general measures as prescribed by the doctor for different causes. 1. Physiological factors: If it is due to the lack of indoor air circulation at night, stifling heat and other causes of night breathing difficulties during the day is fine, it is recommended to maintain indoor ventilation at night, appropriate temperature and humidity, to improve the symptoms of respiratory distress. 2. Bronchial asthma: If bronchial asthma leads to dyspnea at night and nothing during the day, patients can follow the doctor’s instructions to use beclomethasone, budesonide and other anti-inflammatory drugs for inhalation therapy to improve asthma, dyspnea and other symptoms. 3. Left heart failure: If left heart failure causes dyspnea at night and nothing during the day, the patient can keep semi-recumbent position or sitting position to improve the symptoms of dyspnea. If there is no carbon dioxide retention, you can follow the doctor’s instructions for high-flow nasal cannula oxygen therapy. There are many reasons for dyspnea at night and nothing during the day, so it is recommended that the patient go to the hospital in time to have a relevant examination to clarify the cause of the disease and be treated under the guidance of the doctor.