Calf muscles seem to have ants scurrying possible diseases for the lower extremity peripheral neuritis, varicose veins of the lower extremity, lumbar disc herniation compression of the nerve and so on. Treatment includes medication, surgery, physical therapy and so on. 1. Lower extremity peripheral neuritis: refers to peripheral nerve damage caused by various reasons, such as diabetes mellitus late complications, manifested by ants in the skin, numbness, tingling and so on. Commonly used nutritive drugs, such as Epalrestat, methylcobalamin, vitamin B12, vitamin B6. 2. Varicose veins of the lower limbs: Early on, there may be soreness and distension of the lower limbs, and in the later stage, if inflammation occurs, there may be pain, itching and ankylosis, etc. In the early stage, it can be treated by wearing elastic stockings. Early symptoms can be improved by wearing compression stockings. The more serious symptoms can be treated with medication such as sclerosing agents such as polydocanol, sodium tetradecyl sulfate, and intravenous active drugs such as sodium heptasaponin and ethoxyflavone. If conservative treatment is ineffective, endovenous laser cauterization, endoscopic saphenous vein resection and other surgical treatments are feasible. 3. Herniated lumbar disc compressing the nerves: the above symptoms can also occur in this case. Commonly used medications include diclofenac sodium, eperisone, methylcobalamin, etc. Traction and infrared physiotherapy can also be used to relieve symptoms. If conservative treatment fails, minimally invasive surgery such as laminectomy can be used to remove the nucleus pulposus. In addition to the above reasons, mental factors cannot be ruled out. If the above symptoms are not relieved, it is recommended to go to the hospital to find out the cause of the disease and under the guidance of the doctor to carry out regular treatment. The above medications should be applied under the guidance of a pharmacist or doctor, avoiding self-medication.