The fourth generation of cephalosporin has the least side effects, followed by the third generation and the second generation, and the most serious side effects are those of the first generation of cephalosporin. The cephalosporin generation is more common is cefadroxil; the representative drugs of the second generation are cefuroxime sodium and cefamandole; the third generation is currently the most commonly used, and cefotaxime sodium, cefoperazone sulbactam sodium, ceftriaxone and so on are often used in clinical practice; the fourth generation is mainly cefepime, cefpirome and so on. At present, in the clinic, the choice of antibiotics is still mainly based on drug sensitivity tests, to select the most suitable drugs to fight the bacteria in the body, while taking into account the economics of drug use, in the clinic need to be applied under the guidance of doctors. Antibiotics must be used to the cycle, do not use three days to stop, or very easy to appear drug-resistant bacteria.