Bleeding after radiotherapy for esophageal cancer should be stopped in time, fasting water, paying attention to intravenous supplementation of nutrition, and if the patient has serious anemia, blood transfusion can also be performed to improve the patient’s condition. Esophageal cancer is a relatively common malignant tumor in clinic. For those who cannot be removed by surgery or have residual after surgery, radiotherapy is a better treatment method. Radiotherapy will have certain damage to the mucosa of esophagus and the surrounding organs, so it may lead to bleeding. For small amount of bleeding, it is often better to give medicines to stop bleeding and fasting water. If the bleeding occurs due to low platelets, it is necessary to give platelet-boosting treatment after examination to clarify the cause. If the amount of bleeding is relatively large or even life-threatening, interventional or surgical treatment can be considered, and blood transfusion treatment can also be given to avoid hemorrhagic shock. Therefore, if bleeding occurs after radiotherapy for esophageal cancer, corresponding measures should be adopted according to the specific conditions of patients, and hospital consultation is recommended.