Post-operative thyroidectomy generally refers to thyroid cancer, or multinodular goiter. First of all, if the thyroid gland is removed, you need to take eugenol or thyroxine tablets for life to replace the thyroid gland function, the amount of which is usually determined by the patient’s own weight or thyroid hormone level. For benign lesions, the amount of thyroid hormone within the normal and reasonable range should be sufficient, while for malignant thyroids, the amount of thyroxine tablets and euthyroxine should be slightly higher, so that the TSH value can be controlled between 0.1 and 0.5 mIU/L. Secondly, total thyroidectomy can easily cause twitching of the hands and feet or hoarseness, which are caused by damage to the parathyroid glands or nerves. In this case, we should apply nerve-nourishing drugs, such as clinically used methylcobalamin and calcium supplementation drugs including calcium gluconate, which are extremely important for post-operative thyroid maintenance.