In the acute painful period of apical infection, antibiotics are needed to reduce inflammation, such as cephalosporin, amoxicillin and metronidazole tablets, and erythromycin enteric capsules and azithromycin for people who are allergic to penicillin. If acute periapical infection causes severe pain, you can take ibuprofen and fenpropathrin to relieve the pain. Periapical inflammation is caused by pulpitis that is not treated promptly and the inflammation spreads to the root tip. In the acute attack of periapical periodontitis, it will lead to a large amount of inflammatory secretions in the apical area, and even the formation of pus, so the tooth will also have to do root canal treatment to remove the infected decay of the tooth, open the pulp chamber, unblock the root canal, drain the pus, remove the infected pulp, clean and disinfect the root canal, after the root canal treatment removes the source of infection, the inflammation of the root tip will be gradually metabolized and absorbed by the body itself.