Glioma treatment guidelines cite surgical resection as the first option for the treatment of low-grade gliomas. The purpose of surgery is twofold: first, to increase the overall survival of the patient by slowing down the malignant progression of the tumor (low grade to high grade); second, to protect or even improve the neurological function of the patient, thus improving the quality of life. It is important to note that glioma is theoretically incurable, and even if the tumor is removed superficially, it is still difficult to cure. If surgery cannot cure glioma, then functional preservation should be considered at the time of surgery. Therefore, it is necessary to balance the relationship between tumor progression and functional preservation. A staged (multiple) surgery model can be used to remove the tumor and promote functional remodeling (the stimulation of surgery and post-surgical functional recovery and the slow growth of low-grade gliomas can induce functional remodeling). This staged surgical strategy allows to avoid overexertion early in the course of the disease, such as premature application of treatments that will be very useful in the future (e.g. radiotherapy); maintaining the patient’s quality of life by limiting excessive treatments (strikes). We want to try to control the transformation of the tumor to advanced levels by damaging reversible modalities (e.g. surgery, chemotherapy).