High immunoglobulin A may be caused by autoimmune diseases, infectious diseases, chronic liver disease and other factors, the regulation needs to further identify the cause of the disease for targeted drug therapy and other treatments. 1. Autoimmune diseases: Immunoglobulin A is one of the immunoglobulins involved in the immune response in the human body. When there are autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis in the human body, the immunoglobulin A will be elevated, which needs to be treated according to the different causes of the disease by using glucocorticosteroids such as prednisone, immunosuppressants such as cyclophosphamide and other drugs. 2. Infectious diseases: immunoglobulin A is widely present in human mucous membranes and has the function of immune barrier, when there are infectious diseases such as upper respiratory tract infections and urinary tract infections, immunoglobulin A will be elevated, which needs to be treated with appropriate antibiotics according to different causes. 3. Chronic liver disease: Cirrhosis, chronic hepatitis and other chronic liver diseases may also lead to immunoglobulin A will be elevated, this situation needs to be based on different causes of supportive therapy, hepatoprotective therapy and cause-specific drug therapy, while actively treating complications. There may be other reasons for elevated immunoglobulin A. Patients with high immunoglobulin A are advised to go to the Department of Rheumatology and Immunology of regular hospitals for relevant consultation.