In June 2011 with the outbreak of plasticizer in Taiwan, “plasticizer” began to enter the general public’s view. 2012 alcoholic beverage was exposed to plasticizer exceeded 2.6 times the limit of the incident again set off a furor, and eventually became a major food safety incident. So the protagonist of these events “plasticizer” in the end what is it? Why it will be highly regarded by the field of food safety and public health, it has what impact on reproductive health? 1, what is the plasticizer plasticizer is a synthetic organic substances, mainly as plasticizers used to improve plasticity and toughness and widely used in industrial production. In 2010, the global production of phthalate esters reached about 5 million tons. With the rapid development of China’s economy, China has become the world’s largest consumer of phthalates, accounting for 1/4 of global consumption. There are more than 30 kinds of synthetic phthalates, among which low molecular weight phthalates, such as dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP) are mainly used in the production of personal care products and cosmetics, such as Shampoo, body lotion, perfume, hair spray, nail polish, etc., as well as the production of enteric and capsule-type oral drugs; high molecular weight phthalate esters, such as di(2-ethylhexyl) phthalate (DEHP), toluene butyl phthalate (BBP), dioctyl phthalate (DOP) are mainly used in the production of polyvinyl chloride (PVC), involved in food packaging materials (plastic containers The products are used in the manufacture of food packaging materials (plastic containers, tableware, cling film), toys, medical equipment, construction materials and many other products. Among them, DEHP and DBP are the protagonists of the plasticizer fiasco in Taiwan and the alcoholic beverage incident, respectively. Another identity of phthalates is environmental endocrine disruptors (EDCs). Phthalates can interfere with the synthesis, release, transport, binding and metabolism of endocrine hormones when they enter the body, thus affecting human reproductive and endocrine functions. In view of the high health risks of certain phthalates, the World Health Organization, the United States and the European Union have listed six of them as key control pollutants, and China has also included DMP, DEP, DOP three priority control pollutants. 2, plasticizers are everywhere phthalates in plastics when they stay honestly, and humans are peaceful coexistence. But phthalate plasticizers are prone to escape into the environment, which then plays a bad role as an environmental endocrine disruptor. Coupled with the large production and wide application of phthalate ester-based plasticizers, this has led to widespread contamination of various environmental media in China by them and has caused widespread exposure of the population. A large-scale National Population Health and Nutrition Survey (NHANES) by the CDC found that four phthalate metabolites were detected in the urine samples of more than 75% of the general male population. A large-scale cross-sectional study from Prof. Yufeng Li’s group examined the concentrations of eight phthalate metabolites in the urine samples of 1040 male patients attending a fertility center, and seven of the metabolites were detected at >90%. The study found that food is the main source of plasticizer intake, accounting for about 90% of the total intake, followed by drinking water, accounting for about 8%. Plasticizer can enter the body through the digestive system, respiratory system and skin contact and other ways, through the blood circulation into the liver, kidneys, testes and ovaries and other tissues, producing reproductive and developmental toxicity. At present, phthalates and their metabolites have been detected in serum, urine, liver and other human tissues. Notably, phthalates and their metabolites have also been detected in follicular fluid, amniotic fluid, umbilical cord blood, breast milk, semen and other body fluids that are closely related to reproduction and development. Research data from Prof. Yufeng Li’s group showed that the detection rate of certain phthalate metabolites in follicular fluid of infertile women was >72%, suggesting that the ovarian microenvironment of infertile women is commonly exposed to phthalates.