The world’s first “test-tube baby”, Louise Brown, was born on July 25, 1978, at Oldham Hospital in Lancashire, England, a great miracle in the history of human fertility. The birth attracted the attention of scientists around the world, and since then, many countries have followed suit, and IVF has become increasingly popular. IVF technology has been developed from scratch all over the world and has brought blessings to countless families with infertility. However, IVF is also very selective, which diseases can be considered to use IVF to get pregnant? Tubal lesions 1. tubal obstruction, severe tubal adhesions, hydrocele, which cannot be restored by surgical treatment or is estimated to be unable to restore the function of the fallopian tubes; 2. congenital or secondary tubal loss or tubal sterilization without the possibility of recanalization; 3. other obstacles that cause the fallopian tubes to “pick up eggs”. Ovulation disorders Repeated unruptured follicles, ineffective in inducing ovulation by drugs and unsatisfactory follicle development in polycystic ovary syndrome, difficulty in controlling the number of follicle development. Endometriosis Endometriosis combined with infertility or other adjuvant treatment is ineffective in conception. Male factors Low sperm, weak sperm or high rate of sperm malformation, low volume and poor quality of male semen can be manually selected for high quality sperm. V. Congenital diseases Some congenital cervical diseases or cervical injury. VI. Reproductive function reserve Frozen storage is available for women who are at risk of damaging ovarian function due to disease treatment or other reasons. VII. Immunological infertility Immunological infertility and other unexplained infertility. Nowadays, many people think that doing IVF is like buying something, they can take the goods if they give money, they don’t want to treat, or they think about doing IVF when there is a little difficulty in treating less. However, they ignore the most crucial parts: 1. Advanced age is definitely not an indication for IVF; 2, “The success rate of IVF is not that high, and it is not possible to succeed with money. Poor quality of fertilized eggs will naturally increase the chance of IVF failure. We only see that IVF is popular among female celebrities, and many senior celebrities and the general public believe that with IVF, the gestational age can be postponed indefinitely. The key to the success rate of IVF is the age of the woman. As she ages, the number of follicles in her ovaries decreases and the quality of her oocytes decreases, and this decrease in quality especially affects the embryo grade. The success rate of IVF in older patients is lower. We now advocate natural conception, and it is better for both partners to have the same examination and treatment. In conclusion, IVF is not a panacea and should not be relied on excessively.