Pre-pregnancy refers to the early stage of pregnancy, the precautions are proper rest, prohibit coitus, supplement folic acid, careful use of medication, on-time examination and so on. 1. Proper rest: In early pregnancy, you must pay attention to proper rest, avoid exertion and strenuous exercise, and ensure sufficient sleep. 2. Prohibit coitus: the embryo development is unstable during early pregnancy, sexual excitement during coitus will stimulate the uterus and increase the risk of miscarriage, so coitus is not recommended in the first three months of pregnancy. 3. Folic acid supplementation: following the doctor’s advice to continue to supplement folic acid in the first three months of pregnancy can prevent the risk of neural tube malformation in the fetus. 4. Cautious use of medication: Early pregnancy is the stage of embryonic organ differentiation and development, the use of medication at this time may lead to abnormal development of fetal structure, so be careful with the use of medication, and under the guidance of the doctor with the indications of the use of medication, to avoid unnecessary use of medication. 5. Examination on time: ultrasonography should be carried out according to the doctor’s instructions in order to clarify the normal pregnancy, and fetal nuchal translucency thickness measurement should be carried out to preliminarily exclude the risk of chromosomal diseases in the fetus.