After years of exploration and research, the team at the Hand Sweat Disorder Research Laboratory of Fujian Medical University has obtained a number of results in the fields of clinical research, epidemiology, pathogenesis and causative genes, and has published more than 30 papers in authoritative journals at home and abroad. Recently the research on pathogenesis has gained a major breakthrough and was published in the Australian Journal of Neurology (SCI source journal). There are two important findings: 1) myelin thickening in the thoracic sympathetic ganglion, with an increased ratio of unmyelinated to myelinated nerves; 2) Neuregulin-1 is overexpressed in the thoracic sympathetic ganglion. CONCLUSION: Neuregulin-1 is an important factor in the hypermyelination of thoracic sympathetic nerve axons in patients with hand sweating, which leads to increased excitability of the thoracic sympathetic nerves and a faster conduction rate than in normal subjects, resulting in a large amount of sweating of the hands in a short period of time. This is the first time that a study on the pathogenesis of hand sweating has been published internationally, filling a gap in this field.