Kidney function four, urea high, eGFR low usually consider renal insufficiency, should be timely hospital consultation, clear cause, for the cause of drug, surgery or renal replacement therapy, life attention to low salt, low fat, high quality, low protein diet, avoid colds, regular checkups and so on. Kidney function four, urea high, eGFR low should be clear cause, can follow the doctor’s instructions to improve the urine protein quantification, urinary tract CT, renal puncture biopsy and other tests, to clarify the cause of the disease, according to the different causes of the disease to take drugs, surgery or renal replacement therapy. If the above changes are due to urinary tract obstruction, extracorporeal shock wave lithotripsy or nephrolithotripsy can be performed under the guidance of physicians. If it is considered to be caused by chronic renal insufficiency, renal replacement therapy is needed if there are still uncorrectable gastrointestinal reactions, anemia, acidosis, hyperkalemia, water retention and so on after treatment with medicines (such as urethraldehyde granules, renal failure granules, rosasterol, sodium bicarbonate, furosemide, etc.). At the same time, we should pay attention to low-salt, low-fat, high-quality and low-protein diet, monitor blood pressure and blood glucose, avoid exertion, infection, prevent colds, and pay attention to regular rechecking. All of the above medications should be used under the guidance of a professional physician, and patients should not take medication without authorization. When you find high urea and low eGFR, you should consult a regular hospital in time to find out the cause and treat it actively to avoid delay.