Warm and itchy lesions on palms and feet may be caused by eczema, medicinal rashes and hives. 1. Eczema: Eczema usually has symptoms such as rash, itching, erosion, redness and swelling. When eczema appears in the hands and feet location, it may appear such as hot and itchy palms and feet. 2. Drug rash: drug rash usually has the symptoms of erythematous papules and itching in the affected area, and some patients may have symptoms such as high fever and chest tightness. When drug rash appears on the hands and feet, there may be heat and itching on the palms and feet. 3. Urticaria: Urticaria usually has the symptoms of red spots, itching and edema in the affected area in the form of hives. When urticaria occurs on the hands and feet, there may be hot and itchy palms and feet. Hot and itchy palms and feet may have other causes, it is recommended that patients go to the hospital in a timely manner to clarify the cause of the symptoms, under the guidance of the doctor’s treatment.