1.Jaundice: patients with cholangiocarcinoma lack typical symptoms in early stage, and most of them visit the doctor because of jaundice, which is the earliest and most important symptom of cholangiocarcinoma. Jaundice is characterized by progressive aggravation and deepening, and is mostly painless, while a few patients have fluctuating jaundice. Progressive obstructive jaundice is the main symptom of extrahepatic cholangiocarcinoma. 2.Abdominal pain: right upper abdominal pain and distension or fever, weight loss, loss of appetite and other symptoms. 3.Itchy skin: It may appear before or after the appearance of jaundice, and may also be accompanied by other symptoms such as tachycardia, bleeding tendency, mental atrophy, weakness and fatty diarrhea, abdominal distension, etc. The itchy skin is caused by the increase of bilirubin content in blood, which stimulates the peripheral nerves of skin. 4.Other symptoms: along with jaundice, abdominal pain and other symptoms, there are also symptoms such as nausea, vomiting, emaciation, dark yellow urine, such as soy sauce or strong tea-like, light yellow stool or even clay color, etc. In the late stage of tumor rupture, biliary bleeding may occur, black stool, positive stool occult blood test, or even anemia.