Podocytosis is a disease caused by abnormalities of the podocytes in the glomeruli of the kidneys, and can be divided into primary and secondary, with the former having an unknown etiology that may be related to disorders of the immune system, and the latter being seen in diabetes mellitus, infections, and exposure to toxins. Primary podocytosis usually develops as glomerular microscopic lesions, focal segmental glomerulosclerosis, and membranous nephropathy. Secondary podocytosis is common in infection-associated, metalloid-associated, drug-associated, autoimmune, tumor-associated, and renal transplantation-associated membranous nephropathy. Podocytosis is usually manifested as nephrotic syndrome, patients usually have a large amount of proteinuria, some may also have hematuria, found that podocytosis should be as soon as possible to the nephrology department of the hospital, under the guidance of specialists in the use of medication.